TL;DR
Wirecast makes it easy to bring remote guests into your live broadcasts using Skype or ooVoo. Using the built-in Desktop Presenter, you can capture both the video and audio of your caller on a single computer, eliminating the need for complex, multi-computer mixing board setups.
Many of us live streamers do talk interview shows in which the participants are not in your studio. Whether you’re interviewing guests or taking calls from viewers, Wirecast easily integrates with Skype and equivalent video calling services such as ooVoo.
Wirecast has a unique utility called Desktop Presenter. Unlike other screen grabbers DTP (as many of us call it) can bring in audio in addition to video. Also, unlike other screen grabbers, it can bring in both video and audio from other computers on a LAN (Local Area Network) and works cross platform. A wired gigabit network will give you the best performance.
Wirecast-Skype audio setups can be very elaborate with multiple Skype computers all feeding into a mixer with video and audio feeds returning to the guest. While that gives you a lot of control, it can also be an expensive and complicated setup for some. There was a time when certain streaming systems required separate computers, hardware, video and audio inputs, as well as returns for Skype integration. Using Wirecast and DTP, the point of entry can now be a lot less expensive and simple.